By Michelle M. Le Beau, Janet D. Rowley (auth.), Harry Harris, Kurt Hirschhorn (eds.)
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Additional resources for Advances in Human Genetics 15
Arthur and Bloomfield (1983) described five cases (three with AML-M2 and two with AMMoL-M4 leukemia) in which the bone marrow contained an excess of eosinophils (8-54%); all five patients had a deleted chromosome 16 [del(16)(q22)]. Le Beau et al. (1983) reported on a related entity in 18 patients, all of whom had M4 leukemia with eosinophils that showed alterations of morphology, cytochemical reactions, and ultrastructure, in~ cluding the presence of large and irregular basophilic granules, and a positive reaction with periodic-acid-Schiff and chloroacetate esterase.
The significance of these observations will be discussed in a later section. 14q+ A 14q + chromosome is frequently observed in malignant lymphomas, particularly in those of B-cell origin (Mitelman, 1981). This abnormality was observed in 15 patients (7% of patients with abnormalities) studied at the Third Workshop; the 14q + did not result from a translocation of the terminal segment of chromosome 8 in any of these cases. As observed in patients with t(8;14), there was an excess of males over females and of adults over children.
1983; Rowley, 1983b; Fourth International Workshop on Chromosomes in Leukemia, 1984). In the following section we will summarize the findings in our own series of 63 patients with therapy-related ANLL or dysmyelopoietic syndrome (DMPS). Of the 63 previously treated patients, 23 had Hodgkin disease (HD), 10 had non-Hodgkin lymphoma (NHL), 5 had mUltiple myeloma (MM), 1 had hairy cell leukemia, 21 had various solid tumors, and 3 had had a renal transplant. 0 months, respectively. The time to BMD was not associated with the nature of the primary disease or the type of primary therapy.
Advances in Human Genetics 15 by Michelle M. Le Beau, Janet D. Rowley (auth.), Harry Harris, Kurt Hirschhorn (eds.)