Read e-book online Advances in Human Genetics 15 PDF

By Michelle M. Le Beau, Janet D. Rowley (auth.), Harry Harris, Kurt Hirschhorn (eds.)

ISBN-10: 146158356X

ISBN-13: 9781461583561

ISBN-10: 1461583586

ISBN-13: 9781461583585

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Arthur and Bloomfield (1983) described five cases (three with AML-M2 and two with AMMoL-M4 leukemia) in which the bone marrow contained an excess of eosinophils (8-54%); all five patients had a deleted chromosome 16 [del(16)(q22)]. Le Beau et al. (1983) reported on a related entity in 18 patients, all of whom had M4 leukemia with eosinophils that showed alterations of morphology, cytochemical reactions, and ultrastructure, in~ cluding the presence of large and irregular basophilic granules, and a positive reaction with periodic-acid-Schiff and chloroacetate esterase.

The significance of these observations will be discussed in a later section. 14q+ A 14q + chromosome is frequently observed in malignant lymphomas, particularly in those of B-cell origin (Mitelman, 1981). This abnormality was observed in 15 patients (7% of patients with abnormalities) studied at the Third Workshop; the 14q + did not result from a translocation of the terminal segment of chromosome 8 in any of these cases. As observed in patients with t(8;14), there was an excess of males over females and of adults over children.

1983; Rowley, 1983b; Fourth International Workshop on Chromosomes in Leukemia, 1984). In the following section we will summarize the findings in our own series of 63 patients with therapy-related ANLL or dysmyelopoietic syndrome (DMPS). Of the 63 previously treated patients, 23 had Hodgkin disease (HD), 10 had non-Hodgkin lymphoma (NHL), 5 had mUltiple myeloma (MM), 1 had hairy cell leukemia, 21 had various solid tumors, and 3 had had a renal transplant. 0 months, respectively. The time to BMD was not associated with the nature of the primary disease or the type of primary therapy.

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Advances in Human Genetics 15 by Michelle M. Le Beau, Janet D. Rowley (auth.), Harry Harris, Kurt Hirschhorn (eds.)


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