Get Allosteric receptor modulation in drug targeting PDF

By Norman G. Bowery

ISBN-10: 0824727916

ISBN-13: 9780824727918

Delivering a wide range of illustrations and tables in each bankruptcy, this ebook generally covers the foundations of allosterism in connection with drug motion and progresses to an in depth exam of person ionotropic and G-protein coupled receptor systems-helping these new to the topic comprehend the significance of allosterism and delivering these already operating within the box with particular reference info. This name presents in-depth chapters on simple ideas of allosterism and its value at GABAA, 5HT3, nicotinic, and GABAB receptors, ionotropic and metabotropic receptors for glutamate, muscarinic receptors and alpha 2 adrenoceptors to supply an organization starting place to the topic.

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Extra resources for Allosteric receptor modulation in drug targeting

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Trends Pharmacol Sci 2003; 24:346–354. © 2006 by Taylor & Francis Group, LLC Characteristics of Allosterism in Drug Action 37 55. Roettger BF, Ghanekar D, Rao R, et al. Antagonist-stimulated internalization of the G protein-coupled cholecystokinin receptor. Mol Pharmacol 1997; 51: 357–362. 56. Blanpain C Vanderwinden J-M, Cihak J, et al. Multiple active states and oligomerization of CCR5 revealed by functional properties of monoclonal antibodies. Mol Biol Cell 2002; 13:723–737. 57. Tucek S, Proska J.

Metal-ion mediated agonism and agonistenhancement in the melanocortin MC1 and MC4 receptors. J Biol Chem 2002; 277:47662–47670. 58. Swaminath G, Lee TW, Kobilka B. Identification of an allosteric binding site for Zn2þ on the b2 adrenergic receptor. J Biol Chem 2002; 278:352–356. 59. Swaminath G, Steenhuis J, Kobilka B, Lee TW. Allosteric modulation of b2adrenergic receptor by Zn2þ. Mol Pharmacol 2002; 61:65–72. 60. Frederickson CJ. Neurobiology of zinc and zinc-containing neurons. Int Rev Neurobiol 1989; 31:145–238.

Allosteric modulation of b2adrenergic receptor by Zn2þ. Mol Pharmacol 2002; 61:65–72. 60. Frederickson CJ. Neurobiology of zinc and zinc-containing neurons. Int Rev Neurobiol 1989; 31:145–238. 61. Conigrave AD, Quinn SJ, Brown EM. L-amino acid sensing by the extracellular Ca2þ-sensing receptor. Proc Natl Acad Sci USA 2000; 97:4814–4819. 62. Zhang Z, Qiu W, Quinn SJ, Conigrave AD, Brown EM, Bai M. Three adjacent serines in the extracellular domains of the CaR are required for L-amino acid-mediated potentiation of receptor function.

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Allosteric receptor modulation in drug targeting by Norman G. Bowery


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