By Harry G. Brittain
Even supposing the reliable compendia outline a drug substance as to id, purity, power, and caliber, they usually don't supply different actual or chemical info, nor do they checklist equipment of synthesis or pathways of actual or organic degradation and metabolism. Such details is scattered through the medical literature and the records of pharmaceutical laboratories. Edited by means of the affiliate Director of Analytical examine and improvement for the yankee organization of Pharmaceutical Scientists, Analytical Profiles of Drug elements and Excipients brings this knowledge jointly into one resource. The scope of the sequence has lately been extended to incorporate profiles of excipient fabrics.
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Additional info for Analytical Profiles of Drug Substances, Excipients, and Related Methodology
1 Hz) 2 H,, H, GUNAWAN INDRAYANTO ET AL. 22 coupling observed was the coupling between ortho protons (H2 and H,; H, and H,; J = 7-8 Hz). The coupling of meta protons was not observed. 2 I3C-NMR Spectrum The broad band decoupled I3C-NMR spectrum of benzoic acid is shown in Figure 8. 6 MHz. Chemical shifts were measured relative to tetramethylsilane, and assignments for the observed peaks are found in Table 5. 4. Mass Spectrometry The electron impact (Figure 9) and chemical ionization (figures 10 and 1 1) spectra of benzoic acid were obtained using a Finnigan Mat 8200 mass spectrometer.
The rank order in skin permeability of benzoic acid appears to be arm <: abdomen < postauricular < forehead . Downard et al. reported that benzoic acid could induce cutaneous vasodilatation after topical application caused by the local formation of prostaglandin D, in the skin . Benzoic acid can be clinically used to treat hyperammonemia caused by a genetic defect in urea metabolism ~481. G U N A W A N INDRAYANTO ET AL. 42 Yamada et al. suggested that benzoate-metabolizing capacity, especially as indicated by the mean transit time value o;f the serum benzoate, appears to be a better index than the indocyanine green clearance rate for determining hepatic functional reserve in chronic lever disease .
Haensel and R. Stroemmer, GIT Suppl. , 3, 2 1 (1987). 21. Y . Zuying, Chin. Brew, 2, 32 (1983). 22. V. G. Roche, Elelmiszewizsgalati Koezlemenyek, 28, 2 13 (1982). 44 G U N A W A N lNDRAYANTO ET AL. 23. W. Ponder, S. Cliett, E. T. Stewart, J . , 5, 207 (1992). 24. H. Wang, K. Tan, S. Gong, J. Chin. Trad. , 15, 483 (1990). 25. P. Kovacs, J. Plachy, L. Szemere, and I. Racz, Acta Pharm. , 55, 85 (1985). 26. C. Smith, J. Sherma, J. , 8, 103 (1995). 27. H. Qian, W. Yamg, W. Yan, Y. He, and G. Lu, Chin.
Analytical Profiles of Drug Substances, Excipients, and Related Methodology by Harry G. Brittain