Download e-book for iPad: Anatomy of a Scientific Discovery: The Race to Find the by Jeff Goldberg

By Jeff Goldberg

ISBN-10: 1626361932

ISBN-13: 9781626361935

In past due 1973, scientists John Hughes and Hans Kosterlitz spent the vast majority of their time in an underfunded, vague, and cramped laboratory in Aberdeen, Sweden. whereas engaged on the brains of pigs, the duo chanced on a nonaddictive narcotic chemical that they was hoping to later locate in human brains. in the event that they might isolate this chemical in people, probably they can have the opportunity to assist the realm start to heal itself. Hughes and Kosterlitz’s examine could necessarily cause them to realize endorphins, the body’s personal average morphine and the chemical that makes it attainable to believe either ache and pleasure.

Announcing their findings to the clinical international thrust Hughes and Kosterlitz within the highlight and made them celebrities. quickly, scientists around the globe have been swiftly analyzing the human mind and its endorphins. In many years’ time, they might use the team’s preliminary examine to hyperlink endorphins to drug dependancy, runner’s excessive, urge for food keep watch over, sexual reaction, and psychological health problems akin to melancholy and schizophrenia.

In Anatomy of a systematic Discovery, Jeff Goldberg describes Hughes and Kosterlitz’s lives prior to, in the course of, and after their old and clinical step forward. He additionally takes a glance on the larger photo, revealing the brutal pageant among drug businesses to discover the way to take advantage of this huge discovery.

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Additional info for Anatomy of a Scientific Discovery: The Race to Find the Body's Own Morphine

Sample text

Kosterlitz was the source. BRAIN SOUP Hans Kosterlitz’s battered Ford Anglia was parked in its usual spot near the archway in the courtyard of Marishal College when Hughes rolled in. Kosterlitz was seventy-one years old, short, gnome-like, and nearly blind in one eye as the result of a childhood shooting accident. His thick-lensed glasses exaggerated the owlish expression that contributed to his reputation at Aberdeen as a patriarchal sage. Unfortunately for pedestrians, despite his poor eyesight he still drove his car with the same enthusiasm that he showed in pursuing his research.

In fact, to all but a small circle of serious drug researchers in Great Britain and America, his twenty-year romance with the guinea pig ileum was something of a joke, a throwback to turn-of-the-century methods. Medical students at the university had nicknamed him “Mr. ” What it meant was so startling that even Kosterlitz still distrusted his conclusion, which remained known only to his closest colleagues. In the early 1960s—ten years before Hughes’s trips to the slaughterhouse began—Kosterlitz had predicted that morphine worked by imitating a chemical already in the body, an endogenous opiate.

The dead animals were hoisted up on pulleys, plunged into a vat of boiling water to loosen their hides, then fastened by their hind legs to a hook on a moving track. One of the men worked a chainsaw as the bloody carcasses clattered down the line, spilling guts in the mud, toward the bench where Hughes sat. If Hughes’s bribes had been successful—and if there was enough time—the butcher sliced off the pig’s head with a single swipe of the chainsaw and nonchalantly brought it over. If the butcher was too busy, Hughes hacksawed the head off himself, carrying the grisly prize back to his bench.

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Anatomy of a Scientific Discovery: The Race to Find the Body's Own Morphine by Jeff Goldberg

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