By Hyman M., Ed. Schipper
256 pages, sixty seven figures, 6 tables, hardcover This monograph is the 1st of its style to concentration particularly at the function of astroglia in aging-related human neurodegenerative problems and experimental versions of CNS senescence and degeneration. As such, this quantity within the Neuroscience Intelligence Unit sequence represents a unique and significant contribution to the fundamental and scientific neuroscience literature. The chapters are grouped into 3 sections: I. Biology of Astrocytes. The chapters during this part will represent a entire dialogue of the recognized capabilities of astroglia within the mammalian CNS and the jobs those cells might play within the pathophysiology of neurological problems. II. Astrocytes in Human mind Senescence and Neurodegenerative issues. during this part, the pathology of astrocytes and their putative roles in human CNS senescence and numerous neurodegenerative stipulations are lined in enormous aspect. III. Experimental types of Astrocyte Senescence: Implications for Neurodegenerative ! sickness. during this ultimate part, experimental ways to the delineation of the function of astroglia in mind getting older and degeneration are defined. This ebook should still attraction generally to easy neuroscientists attracted to quite a few points of the biology of those cells in addition to to clinically-oriented investigators keen on the pathogenesis of the foremost human neurodegenerative issues.
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Extra info for Astrocytes in Brain Aging and Neurodegeneration (Neuroscience Intelligence Unit 3)
In: Murphy S, ed. Astrocytes, Pharmacology and Function. San Diego: Academic Press, 1993:137. 14. Kimelberg HK, Jalonen T, Walz W. Regulation of the brain microenvironment: Transmitters and ions. In: Murphy S, ed. Astrocytes, Pharmacology and Function. , 1993:193-228. 15. Sontheimer H. Voltage-dependent ion channels in glial cells. Glia 1994; 11:156-172. 16. Takumi T, Ishii T, Horio Y et al. A novel ATP-dependent inward rectifier potassium channel expressed predominantly in glial cells. J Biol Chem 1995; 270:16339-16346.
It would be of considerable interest to see whether this effect has any correlate in vivo, such as in reactive astrogliosis which occurs as a response to neuronal damage and death. Receptors for Transmitters Receptors in Primary Astrocyte Cultures A large number of neurotransmitter receptors have been found in monolayer primary astrocyte cultures prepared from different brain regions of neonatal rats. 86 They have been identified by a variety of techniques, including stimulation of second messengers (cAMP, IP3 or [Ca2+]i), electrophysiological studies, antibody staining, radio-ligand binding studies, and most recently in situ hybridization and RT-PCR for receptor mRNA.
Eur J Neurosci 1995; 7:1188-1198. 43. Steinhäuser C, Jabs R, Kettenmann H. Properties of GABA and glutamate responses in identified glial cells of the mouse hippocampal slice. Hippocampus 1994; 4:19-36. 44. Zalc B, Collet A, Monge M et al. Tamm-Horsfall protein, a kidney marker is expressed on brain sulfogalactosylceramide-positive astroglial structures. Brain Res 1984; 291:182-187. Functions of Astrocytes 33 45. Kettenmann H, Bormann J. Patch-clamp study of gamma-aminobutyric acid receptor Cl– channels in cultured astrocytes.
Astrocytes in Brain Aging and Neurodegeneration (Neuroscience Intelligence Unit 3) by Hyman M., Ed. Schipper